Plasminogen activator Pla
| Plasminogen activator Pla | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.48 | ||||||||
| CAS number | 101028-08-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasminogen activator Pla (EC 3.4.23.48) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Converts human Glu-plasminogen to plasmin by cleaving the Arg560-Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
This enzyme is isolated from the bacterium Yersinia pestis that causes plague.
References
- ↑ Kukkonen, M.; Lähteenmäki, K.; Suomalainen, M.; Kalkkinen, N.; Emödy, L.; Laang, H.; Korhonen, T.K. (2001). "Protein regions important for plasminogen activation and inactivation of α2-antiplasmin in the surface protease Pla of Yersinia pestis". Mol. Microbiol. 40: 1097–1111. doi:10.1046/j.1365-2958.2001.02451.x. PMID 11401715.
External links
- Plasminogen activator Pla at the US National Library of Medicine Medical Subject Headings (MeSH)
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