Plasmepsin II
| Plasmepsin II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.23.39 | ||||||||
| CAS number | 159447-18-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr
This enzyme is present in malaria organism, Plasmodium.
References
- ↑ Dame, J.B.; Reddy, G.R.; Yowell, C.A.; Dunn, B.M.; Kay, J.; Berry, C. (1994). "Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Mol. Biochem. Parasitol. 64: 177–190. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.
- ↑ Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93 (4): 1602–1608. doi:10.1172/JCI117140. PMID 8163662.
- ↑ Hill, J.; Tyas, L.; Phylip, L.H.; Kay, J.; Dunn, B.M.; Berry, C. (1994). "High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Lett. 352 (2): 155–158. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.
External links
- Plasmepsin II at the US National Library of Medicine Medical Subject Headings (MeSH)
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