Pimelyl-(acyl-carrier protein) methyl ester esterase

Pimelyl-(acyl-carrier protein) methyl ester esterase (EC 3.1.1.85, BioH) is an enzyme with systematic name pimelyl-(acyl-carrier protein) methyl ester hydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

pimelyl-[acyl-carrier protein] methyl ester + H₂O

\rightleftharpoons

pimelyl-[acyl-carrier protein] + methanol

References

↑ Sanishvili, R.; Yakunin, A.F.; Laskowski, R.A.; Skarina, T.; Evdokimova, E.; Doherty-Kirby, A.; Lajoie, G.A.; Thornton, J.M.; Arrowsmith, C.H.; Savchenko, A.; Joachimiak, A.; Edwards, A.M. (2003). "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". J. Biol. Chem. 278: 26039–26045. doi:10.1074/jbc.M303867200. PMID 12732651.
↑ Lemoine, Y.; Wach, A.; Jeltsch, J.M. (1996). "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Mol. Microbiol. 19 (3): 645–647. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257.
↑ Tomczyk, N.H.; Nettleship, J.E.; Baxter, R.L.; Crichton, H.J.; Webster, S.P.; Campopiano, D.J. (2002). "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Lett. 513 (2-3): 299–304. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168.
↑ Lin, S.; Hanson, R.E.; Cronan, J.E. (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nat. Chem. Biol. 6 (9): –. doi:10.1038/nchembio.420. PMC 2925990. PMID 20693992.

3.1.1: Carboxylic
ester hydrolases

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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