Phosphonopyruvate hydrolase
| Phosphonopyruvate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.11.1.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a phosphonopyruvate hydrolase (EC 3.11.1.3) is an enzyme that catalyzes the chemical reaction
- 3-phosphonopyruvate + H2O pyruvate + phosphate
Thus, the two substrates of this enzyme are 3-phosphonopyruvate and H2O, whereas its two products are pyruvate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is '. This enzyme is also called PPH'.
References
- Ternan NG, Hamilton JT, Quinn JP (2000). "Initial in vitro characterisation of phosphonopyruvate hydrolase, a novel phosphate starvation-independent, carbon-phosphorus bond cleavage enzyme in Burkholderia cepacia Pal6". Arch. Microbiol. 173 (1): 35–41. doi:10.1007/s002030050005. PMID 10648102.
- Kulakova AN, Wisdom GB, Kulakov LA, Quinn JP (2003). "The purification and characterization of phosphonopyruvate hydrolase, a novel carbon-phosphorus bond cleavage enzyme from Variovorax sp Pal2". J. Biol. Chem. 278 (26): 23426–31. doi:10.1074/jbc.M301871200. PMID 12697754.
- Dunaway-Mariano D, Herzberg O (2006). "Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily". Biochemistry. 45 (38): 11491–504. doi:10.1021/bi061208l. PMID 16981709.
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