Phosphoinositide 5-phosphatase
phosphoinositide 5-phosphatase | |||||||||
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Identifiers | |||||||||
EC number | 3.1.3.36 | ||||||||
CAS number | 9036-01-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a phosphoinositide 5-phosphatase (EC 3.1.3.36) is an enzyme that catalyzes the chemical reaction
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate and H2O, whereas its two products are 1-phosphatidyl-1D-myo-inositol 4-phosphate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. Other names in common use include type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, and phosphatidyl-inositol-bisphosphate phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1UFW, 1W80, 2DNR, and 2QV2.
References
- Dawson RM, Thompson W (1964). "The triphosphoinositide phosphomonoesterase of brain tissue". Biochem. J. 91 (2): 244–50. PMC 1202879. PMID 4284485.
- Roach PD, Palmer FB (1981). "Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase". Biochim. Biophys. Acta. 661 (2): 323–33. doi:10.1016/0005-2744(81)90021-8. PMID 6271223.
- Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.