Phagocyte bactericidal dysfunction

Phagocyte bactericidal dysfunction
Classification and external resources
MeSH	D010585

Phagocyte bactericidal dysfunction refers to a class of medical conditions where phagocytes have a diminished ability to fight bacterial infection.

Examples include:

Hematologic disease: Monocyte and granulocyte disease (CFU-GM/CFU-Baso/CFU-Eos), including immunodeficiency (D70-D71, 288)

Monocytes/
macrophages

↑

Histiocytosis Chronic granulomatous disease

-cytosis:	Monocytosis

↓

-penia:	Monocytopenia

Granulocytes

↑

-cytosis:	granulocytosis Neutrophilia Eosinophilia/Hypereosinophilic syndrome Basophilia Bandemia

↓

-penia:	Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome Eosinopenia Basopenia)

PBD

chemotaxis/degranulation:	Leukocyte adhesion deficiency LAD1 LAD2 Chédiak–Higashi syndrome Neutrophil-specific granule deficiency

respiratory burst:	Chronic granulomatous disease Neutrophil immunodeficiency syndrome Myeloperoxidase deficiency

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