Peptidoglycan-N-acetylglucosamine deacetylase
| Peptidoglycan-N-acetylglucosamine deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.104 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Peptidoglycan-N-acetylglucosamine deacetylase (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglycan deacetylase, N-acetylglucosamine deacetylase, peptidoglycan GlcNAc deacetylase, peptidoglycan N-acetylglucosamine deacetylase, PG N-deacetylase) is an enzyme with systematic name peptidoglycan-N-acetylglucosamine amidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- peptidoglycan-N-acetyl-D-glucosamine + H2O peptidoglycan-D-glucosamine + acetate
This enzyme contributes to virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis.
References
- ↑ Psylinakis, E.; Boneca, I.G.; Mavromatis, K.; Deli, A.; Hayhurst, E.; Foster, S.J.; Varum, K.M.; Bouriotis, V. (2005). "Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis". J. Biol. Chem. 280: 30856–30863. doi:10.1074/jbc.m407426200. PMID 15961396.
- ↑ Tsalafouta, A.; Psylinakis, E.; Kapetaniou, E.G.; Kotsifaki, D.; Deli, A.; Roidis, A.; Bouriotis, V.; Kokkinidis, M. (2008). "Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 203–205. doi:10.1107/s1744309108002510. PMID 18323609.
- ↑ Blair, D.E.; Schuttelkopf, A.W.; MacRae, J.I.; van Aalten, D.M. (2005). "Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor". Proc. Natl. Acad. Sci. USA. 102: 15429–15434. doi:10.1073/pnas.0504339102. PMID 16221761.
- ↑ Wang, G.; Olczak, A.; Forsberg, L.S.; Maier, R.J. (2009). "Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori". J. Biol. Chem. 284: 6790–6800. doi:10.1074/jbc.m808071200. PMID 19147492.
- ↑ Popowska, M.; Kusio, M.; Szymanska, P.; Markiewicz, Z. (2009). "Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis". J. Microbiol. Biotechnol. 19: 932–945. doi:10.4014/jmb.0810.557. PMID 19809250.
- ↑ Fittipaldi, N.; Sekizaki, T.; Takamatsu, D.; de la Cruz Domínguez-Punaro, M.; Harel, J.; Bui, N.K.; Vollmer, W.; Gottschalk, M. (2008). "Significant contribution of the pgdA gene to the virulence of Streptococcus suis". Mol. Microbiol. 70: 1120–1135. doi:10.1111/j.1365-2958.2008.06463.x. PMID 18990186.
External links
- Peptidoglycan-N-acetylglucosamine deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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