POLQ

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4X0P, 4X0Q, 5AGA, 5A9J, 5A9F

Identifiers

Aliases

POLQ, POLH, PRO0327, polymerase (DNA) theta

External IDs

MGI: 2155399 HomoloGene: 32727 GeneCards: POLQ

Gene ontology
Molecular function	• transferase activity • nucleotide binding • DNA binding • nucleotidyltransferase activity • single-stranded DNA-dependent ATPase activity • 5'-deoxyribose-5-phosphate lyase activity • chromatin binding • damaged DNA binding • protein binding • nucleic acid binding • DNA-directed DNA polymerase activity • ATP binding
Cellular component	• nucleoplasm • chromosome • nucleus
Biological process	• DNA-dependent DNA replication • somatic hypermutation of immunoglobulin genes • negative regulation of double-strand break repair via homologous recombination • double-strand break repair via alternative nonhomologous end joining • cellular response to DNA damage stimulus • DNA replication • double-strand break repair via homologous recombination • protein homooligomerization • DNA repair • base-excision repair • DNA biosynthetic process • double-strand break repair
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10721


77782

Ensembl


ENSG00000051341


ENSMUSG00000034206

UniProt


O75417


Q8CGS6

RefSeq (mRNA)


NM_199420


NM_001159369 NM_029977

RefSeq (protein)


NP_955452.3


NP_001152841.1 NP_084253.1

Location (UCSC)

Chr 3: 121.43 – 121.55 Mb

Chr 16: 37.01 – 37.1 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sharief FS, Vojta PJ, Ropp PA, Copeland WC (Aug 1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase". Genomics. 59 (1): 90–6. doi:10.1006/geno.1999.5843. PMID 10395804.
↑ "Entrez Gene: POLQ polymerase (DNA directed), theta".

Hogg M, Sauer-Eriksson AE, Johansson E (2012). "Promiscuous DNA synthesis by human DNA polymerase θ.". Nucleic Acids Research. 40 (6): 2611–2622. doi:10.1093/nar/gkr1102.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Maga G, Shevelev I, Ramadan K, et al. (2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme.". J. Mol. Biol. 319 (2): 359–69. doi:10.1016/S0022-2836(02)00325-X. PMID 12051913.
Seki M, Marini F, Wood RD (2003). "POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells". Nucleic Acids Res. 31 (21): 6117–26. doi:10.1093/nar/gkg814. PMC 275456. PMID 14576298.
Kawamura K, Bahar R, Seimiya M, et al. (2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers". Int. J. Cancer. 109 (1): 9–16. doi:10.1002/ijc.11666. PMID 14735462.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Seki M, Masutani C, Yang LW, et al. (2005). "High-efficiency bypass of DNA damage by human DNA polymerase Q". EMBO J. 23 (22): 4484–94. doi:10.1038/sj.emboj.7600424. PMC 526458. PMID 15496986.
Chiapperino D, Cai M, Sayer JM, et al. (2006). "Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene". J. Biol. Chem. 280 (48): 39684–92. doi:10.1074/jbc.M508008200. PMID 16188888.
Zan H, Shima N, Xu Z, et al. (2005). "The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation". EMBO J. 24 (21): 3757–69. doi:10.1038/sj.emboj.7600833. PMC 1276717. PMID 16222339.
Cruet-Hennequart S, Coyne S, Glynn MT, et al. (2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK". DNA Repair (Amst.). 5 (4): 491–504. doi:10.1016/j.dnarep.2006.01.008. PMID 16520097.
Chen YW, Cleaver JE, Hanaoka F, et al. (2006). "A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents". Mol. Cancer Res. 4 (4): 257–65. doi:10.1158/1541-7786.MCR-05-0118. PMID 16603639.
Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest". Genes Cells. 11 (7): 731–44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.
Choi JY, Stover JS, Angel KC, et al. (2006). "Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site". J. Biol. Chem. 281 (35): 25297–306. doi:10.1074/jbc.M605699200. PMID 16835218.
Kino K, Ito N, Sugasawa K, et al. (2007). "Translesion synthesis by human DNA polymerase eta across oxidative products of guanine". Nucleic Acids Symp Ser (Oxf). 48 (48): 171–2. doi:10.1093/nass/48.1.171. PMID 17150533.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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POLQ

References

Further reading