PGK1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2WZB, 2WZC, 2WZD, 2X13, 2X14, 2X15, 2XE6, 2XE7, 2XE8, 2Y3I, 2YBE, 2ZGV, 3C39, 3C3A, 3C3B, 3C3C, 3ZOZ, 4AXX, 4O33

Identifiers

Aliases

PGK1, HEL-S-68p, MIG10, PGKA, phosphoglycerate kinase 1

External IDs

MGI: 97555 HomoloGene: 21542 GeneCards: PGK1

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein binding • ATP binding • kinase activity • phosphoglycerate kinase activity
Cellular component	• cytoplasm • membrane raft • cytosol • extracellular exosome • membrane
Biological process	• gluconeogenesis • epithelial cell differentiation • glycolytic process • phosphorylation • canonical glycolysis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5230


18655

Ensembl


ENSG00000102144


ENSMUSG00000062070

UniProt


P00558


P09411

RefSeq (mRNA)


NM_000291


NM_008828

RefSeq (protein)


NP_000282.1


NP_032854.2

Location (UCSC)

Chr X: 78.07 – 78.13 Mb

Chr X: 106.19 – 106.2 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene.^[3]^[4]^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:828px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1197px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:801.0px; top:1029.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:555.3333333333333px; top:991.166666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:386.0px; top:594px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:723.0px; top:1086px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.0px; top:140.655462184874px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:882.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:477.6500000000001px; top:942.5px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.99999999999994px; top:432.616246498599px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:384.8991596638656px; top:277.627450980392px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.0px; top:200.655462184874px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:390.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1237px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.99999999999994px; top:502.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:555.3333333333333px; top:891.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:322.9999999999999px; top:981.666666666668px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1137px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:103.366666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:315.274509803922px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1157px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:657.9999999999997px; top:992.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:749px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:696.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:843.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.99999999999994px; top:412.616246498599px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:801.0000000000001px; top:945.5px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:862.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:223.366666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1177px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.99999999999994px; top:542.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:801.0px; top:844px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:470px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:894.366666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:872.3333333333333px; top:893.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:477.6500000000001px; top:844px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:716.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.6666666666666px; height:0px; overflow:hidden; position:relative; left:695.6666666666667px; top:1217px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:477.6500000000001px; top:1029.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:669px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:1033.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.99999999999994px; top:522.666666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.0px; top:180.655462184874px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:872.3333333333334px; top:992.166666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:329.33333333333303px; top:629.666666666666px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:222.5px; top:588.616666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:773.5px; top:1270.7px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.0px; top:160.655462184874px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.9999999999999px; top:349.445378151261px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:386.0px; top:120.655462184874px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:119.22128851540629px; top:246.677871148459px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:119.22128851540629px; top:306.67787114846px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:119.22128851540629px; top:286.67787114846px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:119.22128851540629px; top:266.67787114846px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:117.66666666666674px; top:425.666666666666px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:117.66666666666674px; top:405.666666666666px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:117.66666666666674px; top:445.666666666666px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.3333333333333px; height:0px; overflow:hidden; position:relative; left:125.00000000000004px; top:616.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:63.3333333333333px; height:0px; overflow:hidden; position:relative; left:125.00000000000004px; top:636.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:113.00000000000006px; top:799.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:113.00000000000006px; top:779.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:104.29411764705867px; top:952.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:104.29411764705867px; top:972.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:104.29411764705867px; top:932.333333333333px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:89.0px; top:1044.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:89.0px; top:1064.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:89.0px; top:1104.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:89.0px; top:1084.66666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:100px; height:0px; overflow:hidden; position:relative; left:197.3666666666667px; top:1129.36666666667px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:193px; height:0px; overflow:hidden; position:relative; left:539.9495798319327px; top:314.941176470588px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:163px; height:0px; overflow:hidden; position:relative; left:541.9495798319327px; top:358.941176470588px; background:transparent; border-top:3px green solid"></div>]]

[[<div style="display:block; width:95px; height:0px; overflow:hidden; position:relative; left:870.0px; top:1149px; background:transparent; border-top:3px blue solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:593.0px; top:1076px; background:transparent; border-top:3px green solid"></div>]]

[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:593.0px; top:1096px; background:transparent; border-top:3px blue solid"></div>]]

[[

]]

|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Michelson AM, Markham AF, Orkin SH (May 1983). "Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase". Proc Natl Acad Sci U S A. 80 (2): 472–6. doi:10.1073/pnas.80.2.472. PMC 393400. PMID 6188151.
↑ Singer-Sam J, Keith DH, Tani K, Simmer RL, Shively L, Lindsay S, Yoshida A, Riggs AD (May 1985). "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]". Gene. 32 (3): 409–17. doi:10.1016/0378-1119(84)90016-7. PMID 6099325.
↑ "Entrez Gene: PGK1 phosphoglycerate kinase 1".

Vishwanatha JK, Jindal HK, Davis RG (1992). "The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells.". J. Cell. Sci. 101. ( Pt 1): 25–34. PMID 1533225.
Fujii H, Kanno H, Hirono A, et al. (1992). "A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria.". Blood. 79 (6): 1582–5. PMID 1547346.
Maeda M, Bawle EV, Kulkarni R, et al. (1992). "Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.". Blood. 79 (10): 2759–62. PMID 1586722.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Kumble KD, Vishwanatha JK (1992). "Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells.". J. Cell. Sci. 99. ( Pt 4): 751–8. PMID 1837552.
Maeda M, Yoshida A (1991). "Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu----Pro substitution caused by T/A----C/G transition in exon 3.". Blood. 77 (6): 1348–52. PMID 2001457.
Jindal HK, Vishwanatha JK (1990). "Functional identity of a primer recognition protein as phosphoglycerate kinase.". J. Biol. Chem. 265 (12): 6540–3. PMID 2324090.
Johnson P, Friedmann T (1990). "Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK.". Gene. 88 (2): 207–13. doi:10.1016/0378-1119(90)90033-N. PMID 2347494.
Pfeifer GP, Steigerwald SD, Mueller PR, et al. (1989). "Genomic sequencing and methylation analysis by ligation mediated PCR.". Science. 246 (4931): 810–3. doi:10.1126/science.2814502. PMID 2814502.
Michelson AM, Blake CC, Evans ST, Orkin SH (1985). "Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.". Proc. Natl. Acad. Sci. U.S.A. 82 (20): 6965–9. doi:10.1073/pnas.82.20.6965. PMC 391290. PMID 2995995.
McCarrey JR, Thomas K (1987). "Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene.". Nature. 326 (6112): 501–5. doi:10.1038/326501a0. PMID 3453121.
Fujii H, Yoshida A (1981). "Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia.". Proc. Natl. Acad. Sci. U.S.A. 77 (9): 5461–5. doi:10.1073/pnas.77.9.5461. PMC 350080. PMID 6933565.
Fujii H, Chen SH, Akatsuka J, et al. (1981). "Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia.". Proc. Natl. Acad. Sci. U.S.A. 78 (4): 2587–90. doi:10.1073/pnas.78.4.2587. PMC 319394. PMID 6941312.
Huang IY, Welch CD, Yoshida A (1980). "Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.". J. Biol. Chem. 255 (13): 6412–20. PMID 7391027.
Fujii H, Krietsch WK, Yoshida A (1980). "A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency.". J. Biol. Chem. 255 (13): 6421–3. PMID 7391028.
Huang IY, Fujii H, Yoshida A (1981). "Structure and function of normal and variant human phosphoglycerate kinase.". Hemoglobin. 4 (5-6): 601–9. doi:10.3109/03630268008997730. PMID 7440217.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Hershkovitz M, Riggs AD (1995). "Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2379–83. doi:10.1073/pnas.92.6.2379. PMC 42487. PMID 7892275.

PDB gallery

1hdi: PIG MUSCLE 3-PHOSPHOGLYCERATE KINASE COMPLEXED WITH 3-PG AND MGADP.

1kf0: Crystal Structure of Pig Muscle Phosphoglycerate Kinase Ternary Complex with AMP-PCP and 3PG

1vjc: Structure of pig muscle PGK complexed with MgATP

1vjd: Structure of pig muscle PGK complexed with ATP

This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

PGK1

Interactive pathway map

References

Further reading