ONECUT1

ONECUT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs MGI: 1196423 HomoloGene: 3309 GeneCards: ONECUT1
Orthologs
Species Human Mouse
Entrez

3175

15379

Ensembl

ENSG00000169856

ENSMUSG00000043013

UniProt

Q9UBC0

O08755

RefSeq (mRNA)

NM_004498

NM_008262

RefSeq (protein)

NP_004489.1

NP_032288.1

Location (UCSC) Chr 15: 52.76 – 52.79 Mb Chr 9: 74.86 – 74.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [3]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 8/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.