New York Genome Center

New York Genome Center
Established 2011 (2011)
Research type Basic (non-clinical), Clinical research and translational research
Field of research
 Genomics, Bioinformatics, DNA sequencing, Genome sequencing
Director Robert B. Darnell
Staff 200 (2016)[1]
Location New York City, New York, United States
Affiliations
Website New York Genome Center

The New York Genome Center (NYGC) is a 501(c)(3) nonprofit biomedical research organization in New York, New York.[2] Beginning in 2013, the Center's president and CEO was Robert B. Darnell.[1] As of 2016, though the majority of participating institutions remained New York state-based, three institutions were from outside New York: Stanford University, University of California at Los Angeles and University of Washington.[1]

Founding

The Center was founded in 2011 as a collaboration among twelve academic, medical and industrial partners to advance genome research, each contributing $2.5 million in seed money.[1] McElheny characterized the foundation as consisting of eleven hospitals and academic institutions anchored by the pharmaceutical company Roche and the technology company Illumina.[3] According to McElheny, establishment of the Center was part of a drive to increase New York's reputation in clinical genomics research and was driven in part by philanthropic input from then Mayor Michael Bloomberg.[3] The Center began operation in February 2012.[3]

The founding institutions were:[4]:622

Facility

The Center has 170,000 square feet (16,000 m2) of space in a multi-story building at 101 Avenue of the Americas.[1][5] By the end of 2015, the Center had acquired 14 Illumina HiSeq X Ten sequencing instruments.[6] The focus on HiSeq instruments reflects Illumina having been a founding member of the Center.[4]:622

Finances and projects

As of 2016, the Center's revenue came from US and New York state governments, a contract with 10 medical institutes for central management of clinical data, and a couple of charitable foundations.[1] This includes funds pledged by the Simons Foundation and the Carson Family Charitable Trust of up to $100 million from 2016 to 2019.[7][8]

In 2012, among the first projects the Center engaged in was with founding partner Illumina aimed at determining through whole genome sequencing the genetic basis of susceptibility to Alzheimer's Disease.[4]:421

Government funding has included a $40 million grant in 2016 for establishing a Center for Common Disease Genomics from the National Human Genome Research Institute, the aim of which is to describe a comprehensive list of genes underlying common diseases.[8] Also in 2016, the Center and Weill Cornell Medicine received a National Cancer Institute grant to support a joint cancer genomics data center for the research and clinical interpretation of tumors, a part of the ongoing development of The Cancer Genome Atlas; the grant provides $490,000 per year for five years.[9]

In 2015, the Center won a $13.5 million contract to conduct whole genome sequencing and analysis for the National Heart, Lung, and Blood Institute's TOPMed program.[6][lower-alpha 2]

National Tumor Registry

In February 2016, the Center started a collaboration with IBM to create a tumor registry matching tumor characteristics and therapeutic responsiveness to genetic profiles among cancer patients.[1][10] The work has been part of the US Government Precision Medicine Initiative and has employed the Watson system.[1][10]

Two years prior to this, the Center and IBM collaborated on development of an early version of the tumor registry focused on glioblastoma multiforme,[11] utilizing a pre-production version of Watson Discovery Advisor.[4]:279[12][13][upper-alpha 1]

Notable associates

Notes

  1. ↑ An "associate founding member", though unsure what precisely this means.
  2. ↑ NYGC is among several recipients, another being the Broad Institute.

Publications

  1. ↑ Wrzeszczynski KO, Robine N, Vacic V, Emde AK, Chen BJ, Liao W, Arora K, Shah M, Grabowska EA, Felice V, Dikoglu E, Reeves C, Frank M, Jobanputra V, Zody MC, Bloom T, Darnell RB (2016). (not available in source consulted). AACR 2016. Retrieved 22 November 2016.

References

  1. 1 2 3 4 5 6 7 8 9 Rosenthal, Eric T. (9 March 2016). "A New 'Manhattan Project': New York Genome Center". MedPage Today. Retrieved 21 November 2016.
  2. ↑ Duignan, Christopher (13 August 2015). "Form 990: Return of Organization Exempt From Income Tax" (PDF). GuideStar. p. 1. Retrieved 22 November 2016. (registration required (help)).
  3. 1 2 3 4 5 McElheny, Victor K. (2012). Drawing the Map of Life: Inside the Human Genome Project. New York: Basic Books. pp. 265–6. ISBN 9780465028955. OCLC 770876409 – via Google Books.
  4. 1 2 3 4 Jain, Kewal K. (2015). Textbook of Personalized Medicine (2nd ed.). Humana Press. doi:10.1007/978-1-4939-2553-7. ISBN 9781493925537. OCLC 900623470 – via Google Books.
  5. ↑ Hargittai, István; Hargittai, Magdolna (2016). New York Scientific: A Culture of Inquiry, Knowledge, and Learning. Oxford, United Kingdom: Oxford University Press. p. 167. ISBN 9780191084683 – via Google Books.
  6. 1 2 "NY Genome Center Wins $13.5M from NHLBI Precision Medicine Program". GenomeWeb. 29 October 2015. Retrieved 22 November 2016. (registration required (help)).
  7. ↑ Di Mento, Maria (25 January 2016). "$100 Million for Genome Center and $75 Million for Hospital". Gifts Roundup. The Chronicle of Philanthropy. New York Genome Center. Retrieved 22 November 2016.
  8. 1 2 Lagasse, Jeff (21 January 2016). "New York Genome Center scores $100 million from James Simons, Russell Carson". Healthcare Finance. Retrieved 22 November 2016.
  9. ↑ "Weill Cornell Medicine and the New York Genome Center Awarded NCI Grant to Create Genomic Data Center". Bio-IT World. 3 November 2016. Retrieved 22 November 2016.
  10. 1 2 Cha, Ariana Eunjung (25 February 2016). "IBM and New York Genome Center's new cancer tumor repository aims to revolutionize treatment". The Washington Post. Retrieved 21 November 2016.
  11. ↑ Herper, Matthew (19 March 2014). "IBM's Watson Attempts To Tackle The Genetics Of Brain Cancer". Forbes. Retrieved 22 November 2016.
  12. ↑ Ravindranath, Mohana (29 August 2014). "New Watson incarnation crunches academic literature". The Washington Post. Retrieved 22 November 2016.
  13. ↑ Wang, Baoying (2014). Big Data Analytics in Bioinformatics and Healthcare. Hershey, Pennsylvania: IGI Global. p. 423. ISBN 9781466666122. OCLC 890377536 – via Google Books.
  14. ↑ Reardon, Sara (2015). "Harold Varmus to resign as head of US cancer institute". Nature. doi:10.1038/nature.2015.17063.
  15. ↑ Sunkin-Strube, Alyssa (5 March 2015). "Nobel laureate Harold Varmus to join Weill Cornell April 1". Cornell Chronicle. Retrieved 22 November 2016.
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