Mucorpepsin
| Mucorpepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.23 | ||||||||
| CAS number | 148465-73-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mucorpepsin (EC 3.4.23.23, Mucor rennin, Mucor aspartic proteinase, Mucor acid proteinase, Mucor acid protease, Mucor miehei aspartic proteinase, Mucor miehei aspartic protease, Mucor pusillus emporase, Fromase 100, Mucor pusillus rennin, Fromase 46TL, Mucor miehei rennin) is an enzyme .[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen
This enzyme is isolated from the zygomycete fungi Mucor pusillus and M. miehei.
References
- ↑ Arima, K.; Yu, J.; Iwasaki, S. (1970). "Milk-clotting enzyme from Mucor pusillus var. lindt". Methods Enzymol. 19: 446–459. doi:10.1016/0076-6879(70)19033-1.
- ↑ Ottesen, M.; Rickert, W. (1970). "The acid protease of Mucor miehei". Methods Enzymol. 19: 459–460. doi:10.1016/0076-6879(70)19034-3.
- ↑ Sternberg, M. (1972). "Bond specificity, active site and milk cloting mechanism of the Mucor miehei protease". Biochim. Biophys. Acta. 285: 383–392. doi:10.1016/0005-2795(72)90324-8. PMID 4573298.
- ↑ Oka, T.; Ishino, K.; Tsuzuki, H.; Morihara, K.; Arima, K. (1973). "On the specificity of a rennin-like enzyme from Mucor pusillus". Agric. Biol. Chem. 37: 1177–1184. doi:10.1271/bbb1961.37.1177.
- ↑ Baudy, M.; Foundling, S.; Pavlik, M.; Blundell, T.; Kostka, V. (1988). "Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment". FEBS Lett. 235: 271–274. doi:10.1016/0014-5793(88)81277-8. PMID 3042459.
External links
- Mucorpepsin at the US National Library of Medicine Medical Subject Headings (MeSH)
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