Mir-663 microRNA precursor family
| mir-663 | ||
|---|---|---|
| Identifiers | ||
| Symbol | mir-663 | |
| Rfam | RF00957 | |
| miRBase family | MIPF0000462 | |
| Other data | ||
| RNA type | microRNA | |
| Domain(s) | Eukaryota; | |
In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Gastric cancer suppression
miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer (GC) cell lines. miR-663 introduction into the two human GC cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation.[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B.
miR-155 upregulation and other molecular targets
Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells.[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipolysaccharide upregulation of miR-155 by resveratrol.[3] miR-663 also directly targets EEF1A2, transaltion elongation factor and well-known protooncogene.[2][4]
See also
References
- ↑ Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, et al. (2010). "Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells.". Oncol Rep. 24 (1): 105–12. doi:10.3892/or_00000834. PMID 20514450.
- 1 2 Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMID 23695020.
- ↑ Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, et al. (2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMID 20622002.
- ↑ Anand, N; Murthy, S; Amann, G; Wernick, M; Porter, LA; Cukier, IH; Collins, C; Gray, JW; Diebold, J; Demetrick, DJ; Lee, JM (July 2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.". Nature Genetics. 31 (3): 301–5. doi:10.1038/ng904. PMID 12053177.
Further reading
- Liang, P.; Lv, C.; Jiang, B.; Long, X.; Zhang, P.; Zhang, M.; Xie, T.; Huang, X. (2012). "MicroRNA profiling in denatured dermis of deep burn patients". Burns. 38 (4): 534–540. doi:10.1016/j.burns.2011.10.014. PMID 22360957.
- Lu, J.; Kwan, B. C. H.; Lai, F. M. C. M.; Tam, L. I. S.; Li, E. K. M.; Chow, K. I. M.; Wang, G.; Li, P. K. M. T. O.; Szeto, C. C. (2012). "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology. 17 (4): 346–351. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894.
- Yi, C.; Wang, Q.; Wang, L.; Huang, Y.; Li, L.; Liu, L.; Zhou, X.; Xie, G.; Kang, T.; Wang, H.; Zeng, M.; Ma, J.; Zeng, Y.; Yun, J. -P. (2012). "MiR-663, a microRNA targeting p21WAF1/CIP1, promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma". Oncogene. 31 (41): 4421–4433. doi:10.1038/onc.2011.629. PMID 22249270.
- Yang, Y.; Wang, L. L.; Li, Y. H.; Gao, X. N.; Liu, Y.; Yu, L. (2011). "Effect of CpG Island Methylation on MicroRNA Expression in the k-562 Cell Line". Biochemical Genetics. 50 (1–2): 122–134. doi:10.1007/s10528-011-9478-9. PMID 22089542.
- Marques, F. Z.; Campain, A. E.; Tomaszewski, M.; Zukowska-Szczechowska, E.; Yang, Y. H. J.; Charchar, F. J.; Morris, B. J. (2011). "Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs". Hypertension. 58 (6): 1093–1098. doi:10.1161/HYPERTENSIONAHA.111.180729. PMID 22042811.
- Borgan, E.; Navon, R.; Vollan, H. K. M.; Schlichting, E.; Sauer, T.; Yakhini, Z.; Lingjærde, O. C.; Sørlie, T.; Børresen-Dale, A. L. (2011). "Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue". Molecular Oncology. 5 (6): 564–576. doi:10.1016/j.molonc.2011.08.004. PMID 21917534.
- Tili, E.; Michaille, J. J. (2011). "Resveratrol, MicroRNAs, Inflammation, and Cancer". Journal of Nucleic Acids. 2011: 1–9. doi:10.4061/2011/102431. PMC 3154569
. PMID 21845215. - Yang, Y.; Wang, L. L.; Li, Y. H.; Gao, X. N.; Yu, L. (2011). "Expression level of miRNA-663 in different leukemic cell lines and its biological function". Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology. 19 (2): 279–283. PMID 21518471.
- Jian, P.; Li, Z.; Fang, T.; Jian, W.; Zhuan, Z.; Mei, L.; Yan, W.; Jian, N. (2011). "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology. 4: 20. doi:10.1186/1756-8722-4-20. PMC 3094392. PMID 21518431.
- Ni, C. -W.; Qiu, H.; Jo, H. (2011). "MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells". AJP: Heart and Circulatory Physiology. 300 (5): H1762–H1769. doi:10.1152/ajpheart.00829.2010. PMC 3094086. PMID 21378144.
- Potapova, A.; Albat, C.; Hasemeier, B.; Haeussler, K.; Lamprecht, S.; Suerbaum, S.; Kreipe, H.; Lehmann, U. (2011). "Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution". BMC Biotechnology. 11: 6. doi:10.1186/1472-6750-11-6. PMC 3032674. PMID 21235780.
- Liu, Z. Y.; Zhang, G. L.; Wang, M. M.; Xiong, Y. N.; Cui, H. Q. (2011). "MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation". Asian Pacific Journal of Cancer Prevention. 12 (11): 2819–2823. PMID 22393947.
- Dreher, A.; Rossing, M.; Kaczkowski, B.; Nielsen, F. C.; Norrild, B. (2010). "Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR". Biochemical and Biophysical Research Communications. 403 (3–4): 357–362. doi:10.1016/j.bbrc.2010.11.035. PMID 21078297.
- Tili, E.; Michaille, J. J.; Alder, H.; Volinia, S.; Delmas, D.; Latruffe, N.; Croce, C. M. (2010). "Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells". Biochemical Pharmacology. 80 (12): 2057–2065. doi:10.1016/j.bcp.2010.07.003. PMID 20637737.
- Tili, E.; Michaille, J. -J.; Adair, B.; Alder, H.; Limagne, E.; Taccioli, C.; Ferracin, M.; Delmas, D.; Latruffe, N.; Croce, C. M. (2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–1566. doi:10.1093/carcin/bgq143. PMID 20622002.
- Marasa, B. S.; Srikantan, S.; Martindale, J. L.; Kim, M. M.; Lee, E. K.; Gorospe, M.; Abdelmohsen, K. (2010). "MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence". Aging. 2 (6): 333–343. PMC 2919253. PMID 20606251.
- Te, J. L.; Dozmorov, I. M.; Guthridge, J. M.; Nguyen, K. L.; Cavett, J. W.; Kelly, J. A.; Bruner, G. R.; Harley, J. B.; Ojwang, J. O. (2010). Means, Terry, ed. "Identification of Unique MicroRNA Signature Associated with Lupus Nephritis". PLoS ONE. 5 (5): e10344. doi:10.1371/journal.pone.0010344. PMC 2867940. PMID 20485490.
- Buratti, E.; De Conti, L.; Stuani, C.; Romano, M.; Baralle, M.; Baralle, F. (2010). "Nuclear factor TDP-43 can affect selected microRNA levels". FEBS Journal. 277 (10): 2268–2281. doi:10.1111/j.1742-4658.2010.07643.x. PMID 20423455.
- Maes, O. C.; Sarojini, H.; Wang, E. (2009). "Stepwise up-regulation of MicroRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology. 221 (1): 109–119. doi:10.1002/jcp.21834. PMID 19475566.
- Pizzimenti, S.; Ferracin, M.; Sabbioni, S.; Toaldo, C.; Pettazzoni, P.; Dianzani, M. U.; Negrini, M.; Barrera, G. (2009). "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology and Medicine. 46 (2): 282–288. doi:10.1016/j.freeradbiomed.2008.10.035. PMID 19022373.
- Lehmann, U.; Hasemeier, B.; Römermann, D.; Müller, M.; Länger, F.; Kreipe, H. (2007). "Epigenetic inactivation of microRNA genes in mammary carcinoma". Verhandlungen der Deutschen Gesellschaft fur Pathologie. 91: 214–220. PMID 18314617.
- Lehmann, U.; Hasemeier, B.; Christgen, M.; Müller, M.; Römermann, D.; Länger, F.; Kreipe, H. (2008). "Epigenetic inactivation of microRNA genehsa-mir-9-1in human breast cancer". The Journal of Pathology. 214 (1): 17–24. doi:10.1002/path.2251. PMID 17948228.
External links
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