Methylenediurea deaminase

Methylenediurea deaminase
Identifiers
EC number 3.5.3.21
CAS number 205830-62-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methylenediurea deaminase (EC 3.5.3.21, methylenediurease) is an enzyme with systematic name methylenediurea aminohydrolase.[1] This enzyme catalyses the following chemical reaction

methylenediurea + 2 H2O N-(hydroxymethyl)urea + 2 NH3 + CO2 (overall reaction)
(1a) methylenediurea + H2O N-(carboxyaminomethyl)urea + NH3
(1b) N-(carboxyaminomethyl)urea N-(aminomethyl)urea + CO2 (spontaneous)
(1c) N-(aminomethyl)urea + H2O N-(hydroxymethyl)urea + NH3 (spontaneous)

Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea.

References

  1. Jahns, T., Schepp, R., Kaltwasser, H. (1997). "Purification and characterisation of an enzyme from a strain of Ochrobactrum anthroπ that degrades condensation products of urea and formaldehyde (ureaform)". Can. J. Microbiol. 43: 1111–1117. doi:10.1139/m97-159.
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