Methenyltetrahydromethanopterin cyclohydrolase
| methenyltetrahydromethanopterin cyclohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.4.27 | ||||||||
| CAS number | 99533-50-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a methenyltetrahydromethanopterin cyclohydrolase (EC 3.5.4.27) is an enzyme that catalyzes the chemical reaction
- 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O 5-formyl-5,6,7,8-tetrahydromethanopterin
Thus, the two substrates of this enzyme are 5,10-methenyl-5,6,7,8-tetrahydromethanopterin and H2O, whereas its product is 5-formyl-5,6,7,8-tetrahydromethanopterin.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing). Other names in common use include 5,10-methenyltetrahydromethanopterin cyclohydrolase, N5,N10-methenyltetrahydromethanopterin cyclohydrolase, and methenyl-H4MPT cyclohydrolase. This enzyme participates in folate biosynthesis.
References
- Donnelly MI, Escalante-Semerena JC, Rinehart KL, Wolfe RS (1985). "Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium". Arch. Biochem. Biophys. 242 (2): 430–9. doi:10.1016/0003-9861(85)90227-9. PMID 4062290.