Mannosylglycoprotein endo-beta-mannosidase
| Mannosylglycoprotein endo-beta-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.152 | ||||||||
| CAS number | 141176-95-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mannosylglycoprotein endo-beta-mannosidase (EC 3.2.1.152, endo-beta-mannosidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:
- Hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequences
The substrate group is a substituent on N-4 of an asparagine residue in the glycoprotein.
References
- ↑ Ishimizu, T.; Sasaki, A.; Okutani, S.; Maeda, M.; Yamagishi, M.; Hase, S. (2004). "Endo-β-mannosidase, a plant enzyme acting on N-glycan. Purification, molecular cloning, and characterization". J. Biol. Chem. 279: 38555–38562. doi:10.1074/jbc.m406886200. PMID 15247239.
- ↑ Sasaki, A.; Yamagishi, M.; Mega, T.; Norioka, S.; Natsuka, S.; Hase, S. (1999). "Partial purification and characterization of a novel endo-β-mannosidase acting on N-linked sugar chains from Lilium longiflorum thumb". J. Biochem. (Tokyo). 125: 363–367. doi:10.1093/oxfordjournals.jbchem.a022295. PMID 9990135.
External links
- Mannosylglycoprotein endo-beta-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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