Mannosylfructose-phosphate synthase

Mannosylfructose-phosphate synthase
Identifiers
EC number 2.4.1.246
CAS number 92480-04-1 (not distinguished from EC 2.4.1.167)
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Mannosylfructose-phosphate synthase (EC 2.4.1.246, mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.[1] This enzyme catalyses the following chemical reaction

GDP-mannose + D-fructose 6-phosphate GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity.

References

  1. Torres, L.L.; Salerno, G.L. (2007). "A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases". Proc. Natl. Acad. Sci. USA. 104: 14318–14323. doi:10.1073/pnas.0706709104. PMID 17728402.
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