MZF1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2FI2

Identifiers

Aliases

MZF1, MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6, myeloid zinc finger 1

External IDs

MGI: 107457 HomoloGene: 9633 GeneCards: MZF1

Gene ontology
Molecular function	• transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein homodimerization activity • DNA binding • protein binding • nucleic acid binding • metal ion binding • transcription regulatory region DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7593


109889

Ensembl


ENSG00000099326


ENSMUSG00000030380

UniProt


P28698


n/a

RefSeq (mRNA)


NM_001267033 NM_003422 NM_198055


NM_001290452 NM_001290453 NM_145819

RefSeq (protein)


NP_001253962.1 NP_003413.2 NP_932172.1


n/a

Location (UCSC)

Chr 19: 58.56 – 58.57 Mb

Chr 7: 13.04 – 13.05 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.^[3]^[4]

Interactions

MZF1 has been shown to interact with SCAND1.^[5] MZF-1 has been shown to induce the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. PMID 1860835.
↑ "Entrez Gene: MZF1 myeloid zinc finger 1".
↑ Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
↑ Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.

Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. doi:10.1084/jem.174.5.1097. PMC 2119006. PMID 1719120.
Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene. 254 (1–2): 105–118. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells. 18 (2): 157–62. PMID 15528990.
Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. doi:10.1016/j.jmb.2006.07.063. PMC 1941711. PMID 16950398.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2fi2: Solution structure of the SCAN homodimer from MZF-1/ZNF42

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MZF1

Interactions

References

Further reading