MSC (gene)

MSC
Identifiers
Aliases	MSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDs	MGI: 1333884 HomoloGene: 3738 GeneCards: MSC
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding • protein dimerization activity • transcription corepressor activity Cellular component • nucleus • nucleoplasm Biological process • palate development • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • branchiomeric skeletal muscle development • transcription, DNA-templated • diaphragm development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9242	17681
Ensembl	ENSG00000178860	ENSMUSG00000025930
UniProt	O60682	O88940
RefSeq (mRNA)	NM_005098	NM_010827
RefSeq (protein)	NP_005089.2	NP_034957.1
Location (UCSC)	Chr 8: 71.84 – 71.84 Mb	Chr 1: 14.75 – 14.76 Mb
PubMed search	[1]	[2]
Wikidata

Musculin is a protein that in humans is encoded by the MSC gene.^[3][4][5]

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.^[5]

References

Further reading