MID2

MID2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases MID2, FXY2, MRX101, RNF60, TRIM1, midline 2
External IDs MGI: 1344333 HomoloGene: 8028 GeneCards: MID2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

11043

23947

Ensembl

ENSG00000080561

ENSMUSG00000000266

UniProt

Q9UJV3

Q9QUS6

RefSeq (mRNA)

NM_012216
NM_052817

NM_011845

RefSeq (protein)

NP_036348.2
NP_438112.2

NP_035975.1

Location (UCSC) Chr X: 107.83 – 107.93 Mb Chr X: 140.66 – 140.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Midline-2 is a protein that in humans is encoded by the MID2 gene.[3][4]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[4]

Interactions

MID2 has been shown to interact with MID1.[5][6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Buchner G, Montini E, Andolfi G, Quaderi N, Cainarca S, Messali S, Bassi MT, Ballabio A, Meroni G, Franco B (Sep 1999). "MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development". Hum Mol Genet. 8 (8): 1397–407. doi:10.1093/hmg/8.8.1397. PMID 10400986.
  4. 1 2 "Entrez Gene: MID2 midline 2".
  5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245Freely accessible. PMID 11331580.
  6. Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biol. 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779Freely accessible. PMID 11806752.

Further reading


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