MHC class I polypeptide-related sequence A

MICA

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1B3J, 1HYR

Identifiers

Aliases

MICA, MIC-A, PERB11.1, MHC class I polypeptide-related sequence A

External IDs

GeneCards: MICA

Genetically Related Diseases

rheumatoid arthritis^[1]

Gene ontology
Molecular function	• antigen binding • beta-2-microglobulin binding • protein binding • natural killer cell lectin-like receptor binding
Cellular component	• cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular fluid • cell surface
Biological process	• antigen processing and presentation • cytolysis • adaptive immune response • negative regulation of natural killer cell activation • immune system process • gamma-delta T cell activation • response to heat • immune response to tumor cell • cellular response to DNA damage stimulus • defense response to bacterium • defense response to virus • regulation of immune response • negative regulation of natural killer cell mediated cytotoxicity • viral process • T cell mediated cytotoxicity • natural killer cell mediated cytotoxicity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


100507436


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Ensembl


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UniProt


Q29983


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RefSeq (mRNA)


NM_001289154 NM_000247 NM_001177519 NM_001289152 NM_001289153


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RefSeq (protein)


NP_000238.1


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Location (UCSC)

Chr 6: 31.4 – 31.42 Mb

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PubMed search

^[2]

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Wikidata

View/Edit Human

MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus.^[3] MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.^[3] However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do.^[4] MICA rather functions as a stress-induced ligand for NKG2D receptor.^[5] For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element.^[4] MICA is broadly recognized by NK cells, γδ T cells, and CD8⁺ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.^[5]

References

↑ "Diseases that are genetically associated with MICA view/edit references on wikidata".
↑ "Human PubMed Reference:".
1 2 Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.
1 2 Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.
1 2 Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.

MHC class I polypeptide-related sequence A

See also

References

Further reading