MAPK8IP2

MAPK8IP2
Identifiers
Aliases	MAPK8IP2, IB-2, IB2, JIP2, PRKM8IPL, mitogen-activated protein kinase 8 interacting protein 2
External IDs	MGI: 1926555 HomoloGene: 8201 GeneCards: MAPK8IP2
Gene ontology Molecular function • MAP-kinase scaffold activity • protein complex binding • beta-amyloid binding • structural molecule activity • protein kinase activator activity • protein binding • kinesin binding • protein kinase binding Cellular component • cytoplasm • protein complex • neuronal cell body • intracellular • postsynaptic density Biological process • dendrite morphogenesis • regulation of receptor activity • signal complex assembly • mating behavior • behavioral fear response • MAPK cascade • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity • nonassociative learning • regulation of N-methyl-D-aspartate selective glutamate receptor activity • JNK cascade • regulation of JNK cascade • excitatory postsynaptic potential • social behavior • regulation of synaptic transmission, glutamatergic • positive regulation of stress-activated MAPK cascade • activation of protein kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23542	60597
Ensembl	ENSG00000008735	ENSMUSG00000022619
UniProt	Q13387	Q9ERE9
RefSeq (mRNA)	NM_012324 NM_016431 NM_139124	NM_021921
RefSeq (protein)	NP_036456.1	NP_068740.3
Location (UCSC)	Chr 22: 50.6 – 50.61 Mb	Chr 15: 89.45 – 89.46 Mb
PubMed search	[1]	[2]
Wikidata

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it.^[3][4] The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses,^[5] and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[4]

Interactions

MAPK8IP2 has been shown to interact with MAP3K10,^[3] Mitogen-activated protein kinase 9,^[3] LRP2,^[6][7] LRP1,^[6] MAPK8IP3,^[8] MAP3K12,^[3] MAPK8IP1,^[3] MAP2K7^[3][9] and MAP3K11.^[3]

References

Further reading