Lysosome-associated membrane glycoprotein

Lysosome-associated membrane glycoprotein (Lamp)
Identifiers
Symbol Lamp, LAMP (root symbol of family)
Pfam PF01299
InterPro IPR002000
PROSITE PDOC00280
TCDB 9.A.16
OPM superfamily 516
OPM protein 2mom

Lysosome-associated membrane glycoproteins (lamp)[1][2][3][4] are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bonds. This structure is schematically represented in the figure below.

  +-----+            +-----+         +-----+            +-----+
  |     |            |     |         |     |            |     |
 xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx
 +--------------------------++Hinge++--------------------------++TM++C+

In mammals, there are two closely related types of lamp: LAMP1 and LAMP2.

CD69 (also called gp110 or macrosialin)[5] is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail.

CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).

Human proteins containing this domain

References

  1. ↑ Iwamoto, Tomotada; Sonobe, Toshiaki; Hayashi, Kozaburo (June 2003). "Loop-Mediated Isothermal Amplification for Direct Detection of Mycobacterium tuberculosis Complex, M. avium, and M. intracellulare in Sputum Samples". Journal of Clinical Microbiology. 41 (6): 2616–2622. doi:10.1128/JCM.41.6.2616-2622.2003. PMC 156570Freely accessible. PMID 12791888.
  2. ↑ Nagamine, K.; Hase, T.; Notomi, T. (June 2002). "Accelerated reaction by loop-mediated isothermal amplification using loop primers". Molecular and Cellular Probes. 16 (3): 223–229. doi:10.1006/mcpr.2002.0415. PMID 12144774.
  3. ↑ Notomi, Tsugunori; Okayama, Hiroto; Masubuchi, Harumi; et al. (2000). "Loop-mediated isothermal amplification of DNA". DNA. Nucleic Acids Res. 28 (12): e63. doi:10.1093/nar/28.12.e63. PMC 102748Freely accessible. PMID 10871386.
  4. ↑ Fukuda Minoru (November 1991). "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking" (PDF). J. Biol. Chem. 266 (32): 21327–21330. PMID 1939168.
  5. ↑ Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL (1993). "Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family" (PDF). J. Biol. Chem. 268 (13): 9661–9666. PMID 8486654.

This article incorporates text from the public domain Pfam and InterPro IPR002000

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