Linopristin

Linopristin
Names

IUPAC name N-((6R,9S,10R,13S,15aS,22S,24aS)-22-(4-(dimethylamino)benzyl)-6-ethyl-10,23-dimethyl-18-(morpholinomethyl)-5,8,12,15,21,24-hexaoxo-13-phenyl-2,3,5,6,7,8,9,10,12,13,14,15,15a,16,19,21,22,23,24,24a-icosahydro-1H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl)-3-hydroxypicolinamide
Other names RPR 202698; RPR 202868
Identifiers
CAS Number	325965-23-9^Y
3D model (Jmol)	Interactive image
ECHA InfoCard	100.218.103
UNII	312V80FR4J
SMILES O=C([C@H](CC1=CC=C(N(C)C)C=C1)N(C)C([C@H]2N(CCC2)C3=O)=O)N4[C@H](C(N[C@H](C(O[C@H](C)[C@@H](C(N[C@@H]3CC)=O)NC(C5=NC=CC=C5O)=O)=O)C6=CC=CC=C6)=O)CC=C(CN7CCOCC7)C4
Properties
Chemical formula	C₅₀H₆₃N₉O₁₀
Molar mass	950.11 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Linopristin is an antibiotic of the streptogramin B class. It is one of the components of the antibiotic combination NXL103.^[1]

References

↑ Pankuch, Glenn A.; Kelly, Linda M.; Lin, Gengrong; Bryskier, Andre; Couturier, Catherine; Jacobs, Michael R.; Appelbaum, Peter C. (2003). "Activities of a new oral streptogramin, XRP 2868, compared to those of other agents against Streptococcus pneumoniae and Haemophilus species". Antimicrobial Agents and Chemotherapy. 47 (10): 3270–3274. doi:10.1128/AAC.47.10.3270-3274.2003. PMC 201162. PMID 14506040.

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