Leukotriene-C4 synthase
| leukotriene-C4 synthase | |||||||||
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Leukotriene C4 synthase dodekamer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 4.4.1.20 | ||||||||
| CAS number | 90698-32-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a leukotriene-C4 synthase (EC 4.4.1.20) is an enzyme that catalyzes the chemical reaction
- leukotriene C4 leukotriene A4 + glutathione
Hence, this enzyme has one substrate, leukotriene C4, and two products, leukotriene A4 and glutathione.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-, tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-, and 7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2PNO, 2UUH, and 2UUI.
References
- Bach MK, Brashler JR, Morton DR Jr (1984). "Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase". Arch. Biochem. Biophys. 230 (2): 455–65. doi:10.1016/0003-9861(84)90426-0. PMID 6324687.
- Shimizu T (1988). "Enzymes functional in the syntheses of leukotrienes and related compounds". Int. J. Biochem. 20 (7): 661–6. doi:10.1016/0020-711X(88)90160-7. PMID 2846379.
- Lam BK, Austen KF (2002). "Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes". Prostaglandins. Other. Lipid. Mediat. 68-69: 511–20. doi:10.1016/S0090-6980(02)00052-7. PMID 12432940.
- Christmas P, Weber BM, McKee M, Brown D, Soberman RJ (2002). "Membrane localization and topology of leukotriene C4 synthase". J. Biol. Chem. 277 (32): 28902–8. doi:10.1074/jbc.M203074200. PMID 12023288.