LLGL1

LLGL1
Identifiers
Aliases LLGL1, DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1, scribble cell polarity complex component
External IDs MGI: 102682 HomoloGene: 31220 GeneCards: LLGL1
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

3996

16897

Ensembl

ENSG00000131899

ENSMUSG00000020536

UniProt

Q15334

Q80Y17

RefSeq (mRNA)

NM_004140

NM_001159404
NM_001159405
NM_008502

RefSeq (protein)

NP_004131.3

NP_001152876.1
NP_001152877.1
NP_032528.1

Location (UCSC) Chr 17: 18.23 – 18.24 Mb Chr 11: 60.7 – 60.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.[3][4][5]

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF, et al. (Aug 1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain". Oncogene. 11 (2): 291–301. PMID 7542763.
  4. Koyama K, Fukushima Y, Inazawa J, Tomotsune D, Takahashi N, Nakamura Y (Mar 1996). "The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2". Cytogenet Cell Genet. 72 (1): 78–82. doi:10.1159/000134167. PMID 8565641.
  5. 1 2 "Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)".

Further reading


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