Kopexil
 | |
| Names | |
|---|---|
| IUPAC names
2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine 2,4-Diaminopyrimidine 3-N-oxide | |
| Other names
Aminexil | |
| Identifiers | |
113275-13-1  74638-76-9 (pyridine oxide tautomer) | |
| Properties | |
| C4H6N4O | |
| Molar mass | 126.12 g·mol−1 |
| Appearance | white odorless crystals[1] |
| Melting point | 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1] |
| slightly soluble[1] | |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.
Chemical structure
Kopexil is an N-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.
Mechanism of action
The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]
References
- 1 2 3 MSDS for Kopexil at Kumar Organics. March 28th 2012.
- ↑ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
- ↑ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).
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