Kallikrein 13
| Kallikrein 13 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.119 | ||||||||
| CAS number | 342900-44-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Kallikrein 13 (EC 3.4.21.119, KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin
This enzyme belongs in peptidase family S1A.
References
- ↑ Nakayama, K.; Kim, W.S.; Nakagawa, T.; Nagahama, M.; Murakami, K. (1990). "Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis". J. Biol. Chem. 265: 21027–21031. PMID 2250008.
- ↑ Kim, W.S.; Hatsuzawa, K.; Ishizuka, Y.; Hashiba, K.; Murakami, K.; Nakayama, K. (1990). "A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization". J. Biol. Chem. 265: 5930–5933. PMID 2180937.
- ↑ Kikkawa, Y.; Yamanaka, N.; Tada, J.; Kanamori, N.; Tsumura, K.; Hosoi, K. (1998). "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". Biochim. Biophys. Acta. 1382: 55–64. doi:10.1016/s0167-4838(97)00144-1. PMID 9507064.
- ↑ Yao, C.; Karabasil, M.R.; Purwanti, N.; Li, X.; Akamatsu, T.; Kanamori, N.; Hosoi, K. (2006). "Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1β in the submandibular gland of mice". J. Biol. Chem. 281: 7968–7976. doi:10.1074/jbc.m507705200. PMID 16423834.
External links
- Kallikrein 13 at the US National Library of Medicine Medical Subject Headings (MeSH)
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