JAG2

Identifiers

JAG2, HJ2, SER2, jagged 2

External IDs

MGI: 1098270 HomoloGene: 1677 GeneCards: JAG2

Gene ontology
Molecular function	• calcium ion binding • Notch binding • protein binding • growth factor activity
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane
Biological process	• Notch signaling pathway • skeletal system development • cell differentiation • respiratory system process • regulation of cell migration • epithelial cell apoptotic process involved in palatal shelf morphogenesis • in utero embryonic development • multicellular organism development • odontogenesis of dentin-containing tooth • cell communication • auditory receptor cell fate commitment • T cell differentiation • regulation of cell adhesion • regulation of cell proliferation • spermatogenesis • Notch receptor processing • cell cycle • morphogenesis of embryonic epithelium • gamma-delta T cell differentiation • thymic T cell selection • positive regulation of Notch signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3714


16450

Ensembl


ENSG00000184916


ENSMUSG00000002799

UniProt


Q9Y219


Q9QYE5

RefSeq (mRNA)


NM_002226 NM_145159


NM_010588

RefSeq (protein)


NP_002217.3 NP_660142.1


NP_034718.2

Location (UCSC)

Chr 14: 105.14 – 105.17 Mb

Chr 12: 112.91 – 112.93 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Protein jagged-2 is a protein that in humans is encoded by the JAG2 gene.^[3]^[4]^[5]

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

JAG2 has been shown to interact with NOTCH2.^[6]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. PMC 232455. PMID 9315665.
↑ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
1 2 "Entrez Gene: JAG2 jagged 2".
↑ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
↑ Wang; Remke; Bhat; Wong; Zhou; Ramaswamy; Dubuc; Fonkem; Salem; Zhang; Hsieh; O'Rourke; Wu; Li; Hawkins; Kohane; Wu; Wu; Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel bilogical target in high-risk medulloblastoma". Oncotarget. 6: 2709–24. doi:10.18632/oncotarget.2779. PMID 25576913.

Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi:10.1006/dbio.1996.0310. PMID 8948600.
Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. doi:10.1016/S0925-4773(97)00146-9. PMID 9486542.
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID 10080181.
Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. doi:10.1093/intimm/11.7.1017. PMID 10383933.
Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood. 96 (3): 950–7. PMID 10910909.
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID 11056013.
Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L (2001). "Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction". Am. J. Pathol. 159 (3): 875–83. doi:10.1016/S0002-9440(10)61763-4. PMC 1850458. PMID 11549580.
Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. PMID 11700865.
Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200. PMID 12551931.
Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 (12): 3697–704. doi:10.1182/blood-2003-12-4114. PMID 15292061.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Yao Y, Yao J, Radparvar M, Blazquez-Medela AM, Guihard PJ, Jumabay M, Boström KI (2013). "Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.". Proc. Natl. Acad. Sci. U.S.A. 110 (47): 19071–6. doi:10.1073/pnas.1310905110. PMID 24191040.

Signaling pathway: notch signaling pathway

Receptor on signaling cell	Delta DLL1 DLL3 DLL4

Ligand	Jagged JAG1 JAG2

Receptor on receiving cell	Notch 1 Notch 2 Notch 3 Notch 4

This article is issued from Wikipedia - version of the 11/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

JAG2

Function

Interactions

References

Further reading