Isopentenyl-diphosphate Delta-isomerase
| isopentenyl-diphosphate delta-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.3.2 | ||||||||
| CAS number | 9033-27-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an isopentenyl-diphosphate Delta-isomerase (EC 5.3.3.2, see also: Isopentenyl Pyrophosphate) is an enzyme that catalyzes the chemical reaction
- isopentenyl diphosphate dimethylallyl diphosphate
Hence, this enzyme has one substrate, isopentenyl diphosphate, and one product, dimethylallyl diphosphate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is isopentenyl-diphosphate Delta3-Delta2-isomerase. Other names in common use include isopentenylpyrophosphate Delta-isomerase, methylbutenylpyrophosphate isomerase, and isopentenylpyrophosphate isomerase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis.
Structural studies
As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes 1HX3, 1HZT, 1I9A, 1NFS, 1NFZ, 1OW2, 1P0K, 1P0N, 1PPV, 1PPW, 1PVF, 1Q54, 1R67, 1VCF, 1VCG, 1X83, 1X84, 2B2K, 2DHO, 2G73, 2G74, 2I6K, 2ICJ, 2ICK, and 2PNY.
References
- Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001). "An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 932–7. doi:10.1073/pnas.020472198. PMC 14687
. PMID 11158573. - Bishop JM (1983). "Cellular oncogenes and retroviruses". Annu. Rev. Biochem. 52: 301–54. doi:10.1146/annurev.bi.52.070183.001505. PMID 6351725.
- AGRANOFF BW, EGGERER H, HENNING U, LYNEN F (1960). "Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase". J. Biol. Chem. 235: 326–32. PMID 13792054.