Isohexenylglutaconyl-CoA hydratase
| isohexenylglutaconyl-CoA hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.57 | ||||||||
| CAS number | 37290-84-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, an isohexenylglutaconyl-CoA hydratase (EC 4.2.1.57) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
Hence, this enzyme has one substrate, 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA, and two products, 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]. Other names in common use include 3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase, isohexenylglutaconyl coenzyme A hydratase, beta-isohexenylglutaconyl-CoA-hydratase, and 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase.
References
- SEUBERT W, FASS E (1964). "[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]". Biochem. Z. 341: 23–34. PMID 14339651.