Iota-carrageenase

Identifiers

Databases

PDB structures

Iota-carrageenase (EC 3.2.1.157) is an enzyme with systematic name iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Endohydrolysis of (1->4)-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans

The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate.

References

↑ Barbeyron, T.; Michel, G.; Potin, P.; Henrissat, B.; Kloareg, B. (2000). "ι-Carrageenases constitute a novel family of glycoside hydrolases, unrelated to that of κ-carrageenases". J. Biol. Chem. 275 (45): 35499–35505. doi:10.1074/jbc.m003404200. PMID 10934194.
↑ Michel, G.; Chantalat, L.; Fanchon, E.; Henrissat, B.; Kloareg, B.; Dideberg, O. (2001). "The ι-carrageenase of Alteromonas fortis. A β-helix fold-containing enzyme for the degradation of a highly polyanionic polysaccharide". J. Biol. Chem. 276 (43): 40202–40209. doi:10.1074/jbc.M100670200. PMID 11493601.
↑ Michel, G.; Helbert, W.; Kahn, R.; Dideberg, O.; Kloareg, B. (2003). "The structural bases of the processive degradation of ι-carrageenan, a main cell wall polysaccharide of red algae". J. Mol. Biol. 334 (3): 421–433. doi:10.1016/j.jmb.2003.09.056. PMID 14623184.

Iota-carrageenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase

Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme

Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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