Intermediate cleaving peptidase 55
| Intermediate cleaving peptidase 55 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.11.26 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Intermediate cleaving peptidase 55 (EC 3.4.11.26, Icp55, mitochondrial intermediate cleaving peptidase 55 kDa) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Icp55 removes the destabilizing N-terminal amino acid residues.
References
- ↑ Naamati, A.; Regev-Rudzki, N.; Galperin, S.; Lill, R.; Pines, O. (2009). "Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55". J. Biol. Chem. 284: 30200–30208. doi:10.1074/jbc.M109.034694. PMID 19720832.
- ↑ Vogtle, F.N.; Wortelkamp, S.; Zahedi, R.P.; Becker, D.; Leidhold, C.; Gevaert, K.; Kellermann, J.; Voos, W.; Sickmann, A.; Pfanner, N.; Meisinger, C. (2009). "Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability". Cell. 139: 428–439. doi:10.1016/j.cell.2009.07.045. PMID 19837041.
External links
- Intermediate cleaving peptidase 55 at the US National Library of Medicine Medical Subject Headings (MeSH)
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