Indoleacetate—lysine synthetase
indoleacetate-lysine synthetase | |||||||||
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Identifiers | |||||||||
EC number | 6.3.2.20 | ||||||||
CAS number | 103537-15-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an indoleacetate-lysine synthetase (EC 6.3.2.20) is an enzyme that catalyzes the chemical reaction
- ATP + (indol-3-yl)acetate + L-lysine ADP + phosphate + N6-[(indol-3-yl)acetyl]-L-lysine
The 3 substrates of this enzyme are ATP, (indol-3-yl)acetate, and L-lysine, whereas its 3 products are ADP, phosphate, and [[N6-[(indol-3-yl)acetyl]-L-lysine]].
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is (indol-3-yl)acetate:L-lysine ligase (ADP-forming). This enzyme is also called indoleacetate:L-lysine ligase (ADP-forming).
References
- Glass NL, Kosuge T (1986). "Cloning of the gene for indoleacetic acid-lysine synthetase from Pseudomonas syringae subsp. savastanoi". J. Bacteriol. 166 (2): 598–603. PMC 214646. PMID 3084452.
- Hutzinger O, Kosuge T (1968). "Microbial synthesis and degradation of indole-3-acetic acid. 3. The isolation and characterization of indole-3-acetyl-epsilon-L-lysine". Biochemistry. 7 (2): 601–5. doi:10.1021/bi00842a013. PMID 5644130.
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