Ilepcimide

Ilepcimide
Clinical data

ATC code	none
Identifiers
IUPAC name (E)-3-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylprop-2-en-1-one
CAS Number	23434-86-8^Y
PubChem (CID)	641115
ChemSpider	556435^N
UNII	5ML58O200F^Y
Chemical and physical data
Formula	C₁₅H₁₇NO₃
Molar mass	259.300 g/mol
3D model (Jmol)	Interactive image
SMILES C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3
InChI InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+^N Key:BLPUOQGPBJPXRL-FNORWQNLSA-N^N
^NY (what is this?) (verify)

Ilepcimide, also known as antiepilepserine, is a anticonvulsant.^[1] It is a piperidine derivative that was first synthesized by Chinese researchers as an analogue of piperine, the main alkaloid and phytochemical of black pepper (and of other plants in the Piperaceae family).

Ilepcimide has serotonergic activity.^[1]^[2]^[3]

References

1 2 C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012.
↑ Liu, G.Q., Algeria, S., Ceci, A., Gerattini, S., Gobi, M. and Murai, S. (1984). "Stimulation of serotonin synthesis in rat brain after antiepilepserine, an antiepileptic piperine derivative". Biochemical Pharmacology. 33: 3883–3886. doi:10.1016/0006-2952(84)90055-8.
↑ Yan, Q.S., Mishra, P.K., Burger, R.L., Bettendorf, A.F., Jobe, P.C. and Dailey J.W. (1992). "Evidence that carbamazepine and antiepilepserine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats". J. Pharm & Exp Therap. 261 (2): 652–659.

GABA_AR PAMs	Barbiturates: Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital^# Primidone; Carbamates: Felbamate; Benzodiazepines: Clobazam Clonazepam Clorazepate Diazepam^# Lorazepam^# Midazolam Nimetazepam Nitrazepam Temazepam; Others: Bromide (potassium bromide, sodium bromide) Paraldehyde Stiripentol

GABA-T inhibitors	Fatty acids: Valproate Valpromide Valproate pivoxil; Others: Ethanolamine-O-sulfate Vigabatrin

Others	GABAR agonists: Progabide; GAT-1 inhibitors: Tiagabine

Sodium blockers	Hydantoins: Ethotoin Fosphenytoin Mephenytoin Phenytoin^#; Ureides: Acetylpheneturide Chlorphenacemide Phenacemide^‡ Pheneturide; Fatty acids: Valproate Valpromide Valproate pivoxil; Carboxamides: Carbamazepine^# Eslicarbazepine acetate Oxcarbazepine; Others: Lacosamide Lamotrigine Rufinamide Topiramate Zonisamide

Calcium blockers	Oxazolidinediones: Ethadione Paramethadione Trimethadione; Succinimides: Ethosuximide^# Mesuximide Phensuximide; Gabapentinoids: Gabapentin Pregabalin; Others: Lamotrigine Topiramate Zonisamide

Potassium openers	Retigabine

Others

CA inhibitors	Sulfonamides: Acetazolamide Ethoxzolamide Sultiame Topiramate Zonisamide

Others	Beclamide Brivaracetam Levetiracetam Perampanel

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