IPO8
| IPO8 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | IPO8, RANBP8, importin 8 | ||||||||||||||||
| External IDs | MGI: 2444611 HomoloGene: 48430 GeneCards: IPO8 | ||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 12: 30.63 – 30.7 Mb | Chr 6: 148.77 – 148.83 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
Importin 8 is a protein that in humans is encoded by the IPO8 gene.[3]
Function
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
References
Further reading
- Görlich, D.; Dabrowski, M.; Bischoff, F. R.; Kutay, U.; Bork, P.; Hartmann, E.; Prehn, S.; Izaurralde, E. (1997). "A novel class of RanGTP binding proteins". The Journal of Cell Biology. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951
. PMID 9214382. - Nozawa, R. S.; Nagao, K.; Masuda, H. T.; Iwasaki, O.; Hirota, T.; Nozaki, N.; Kimura, H.; Obuse, C. (2010). "Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation". Nature Cell Biology. 12 (7): 719–727. doi:10.1038/ncb2075. PMID 20562864.
- Lunetta, K. L.; d'Agostino Rb, R. B.; Karasik, D.; Benjamin, E. J.; Guo, C. Y.; Govindaraju, R.; Kiel, D. P.; Kelly-Hayes, M.; Massaro, J. M.; Pencina, M. J.; Seshadri, S.; Murabito, J. M. (2007). "Genetic correlates of longevity and selected age-related phenotypes: A genome-wide association study in the Framingham Study". BMC Medical Genetics. 8: S13. doi:10.1186/1471-2350-8-S1-S13. PMC 1995604. PMID 17903295.
- Nguewa, P. A.; Agorreta, J.; Blanco, D.; Lozano, M.; Gomez-Roman, J.; Sanchez, B. A.; Valles, I. A.; Pajares, M. J.; Pio, R.; Rodriguez, M.; Montuenga, L. M.; Calvo, A. (2008). "Identification of Importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens". BMC Molecular Biology. 9: 103. doi:10.1186/1471-2199-9-103. PMC 2612021. PMID 19014639.
- Dean, K. A.; Von Ahsen, O.; Görlich, D.; Fried, H. M. (2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". Journal of Cell Science. 114 (Pt 19): 3479–3485. PMID 11682607.
- Weinmann, L.; Höck, J.; Ivacevic, T.; Ohrt, T.; Mütze, J. R.; Schwille, P.; Kremmer, E.; Benes, V.; Urlaub, H.; Meister, G. (2009). "Importin 8 is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs". Cell. 136 (3): 496–507. doi:10.1016/j.cell.2008.12.023. PMID 19167051.
- Yao, X.; Chen, X.; Cottonham, C.; Xu, L. (2008). "Preferential Utilization of Imp7/8 in Nuclear Import of Smads". Journal of Biological Chemistry. 283 (33): 22867–22874. doi:10.1074/jbc.M801320200. PMC 2504884. PMID 18519565.
- Zuo, S.; Xue, Y.; Tang, S.; Yao, J.; Du, R.; Yang, P.; Chen, X. (2010). "14-3-3 Epsilon Dynamically Interacts with Key Components of Mitogen-Activated Protein Kinase Signal Module for Selective Modulation of the TNF-α-Induced Time Course-Dependent NF-κB Activity". Journal of Proteome Research. 9 (7): 3465–3478. doi:10.1021/pr9011377. PMID 20462248.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.