IPO7

IPO7
Identifiers
Aliases IPO7, Imp7, RANBP7, importin 7
External IDs MGI: 2152414 HomoloGene: 4659 GeneCards: IPO7
Orthologs
Species Human Mouse
Entrez

10527

233726

Ensembl

ENSG00000205339

ENSMUSG00000066232

UniProt

O95373

Q9EPL8

RefSeq (mRNA)

NM_006391

NM_181517

RefSeq (protein)

NP_006382.1

NP_852658.2

Location (UCSC) Chr 11: 9.38 – 9.45 Mb Chr 7: 110.02 – 110.06 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Importin-7 is a protein that in humans is encoded by the IPO7 gene.[3][4]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (Aug 1997). "A novel class of RanGTP binding proteins". J Cell Biol. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951Freely accessible. PMID 9214382.
  4. 1 2 "Entrez Gene: IPO7 importin 7".

Further reading


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