Human endogenous retrovirus K endopeptidase
| Human endogenous retrovirus K endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.50 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Human endogenous retrovirus K endopeptidase (EC 3.4.23.50, human endogenous retrovirus K10 endopeptidase, endogenous retrovirus HERV-K10 putative protease, human endogenous retrovirus K retropepsin, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K113 protease, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-PIVQ- cleavage site.
This enzyme belongs to the peptidase family A2.
References
- ↑ Towler, E.M., Gulnik, S.V., Bhat, T.N., Xie, D., Gustschina, E., Sumpter, T.R., Robertson, N., Jones, C., Sauter, M., Mueller-Lantzsch, N., Debouck, C. and Erickson, J.W. (1998). "Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease". Biochemistry. 37: 17137–17144. doi:10.1021/bi9818927. PMID 9860826.
External links
- Human endogenous retrovirus K endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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