HLA-DRB5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FV1, 1H15, 1HQR, 1ZGL

Identifiers

Aliases

HLA-DRB5, HLA-DRB, major histocompatibility complex, class II, DR beta 5

External IDs

OMIM: 604776 MGI: 95901 HomoloGene: 101524 GeneCards: HLA-DRB5

Gene ontology
Molecular function	• peptide antigen binding
Cellular component	• integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endosome • Golgi apparatus • trans-Golgi network membrane • endoplasmic reticulum membrane • membrane • late endosome membrane • Golgi membrane • plasma membrane • transport vesicle membrane • MHC class II protein complex • lysosomal membrane • endoplasmic reticulum • ER to Golgi transport vesicle membrane • lysosome • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane • extracellular exosome
Biological process	• antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • T cell receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3127


14969

Ensembl


ENSG00000198502


ENSMUSG00000060586

UniProt


Q30154


P04231 P04230 P18468 P18469

RefSeq (mRNA)


NM_002125


NM_010382

RefSeq (protein)


NP_002116.2


n/a

Location (UCSC)

Chr 6: 32.52 – 32.53 Mb

Chr 17: 34.31 – 34.32 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.^[3]

Function

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).^[3]

Gene structure and polymorphisms

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.^[3]

Gene expression

DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.^[3]

References

Lau M, Terasaki PI, Park MS (1995). "International Cell Exchange, 1994.". Clinical transplants: 467–88. PMID 7547576.
Dong RP, Kimura A, Sasazuki T (1992). "Sequence analysis of three novel DRw14-DRB1 alleles.". Immunogenetics. 36 (2): 130–3. doi:10.1007/BF00215291. PMID 1612646.
Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120.". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305.
Nong Y, Kandil O, Tobin EH, et al. (1991). "The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.". Cell. Immunol. 132 (1): 10–6. doi:10.1016/0008-8749(91)90002-S. PMID 1905983.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion.". J. Immunol. 144 (2): 526–31. PMID 1967269.
Callahan KM, Fort MM, Obah EA, et al. (1990). "Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.". J. Immunol. 144 (9): 3341–6. PMID 1970352.
Petersdorf EW, Griffith RL, Erlich HA, et al. (1990). "Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes.". Immunogenetics. 32 (2): 96–103. doi:10.1007/BF00210446. PMID 1975801.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
Gyllensten UB, Sundvall M, Erlich HA (1991). "Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3686–90. doi:10.1073/pnas.88.9.3686. PMC 51517. PMID 2023919.
Lee KW, Johnson AH, Hurley CK (1990). "Two divergent routes of evolution gave rise to the DRw13 haplotypes.". J. Immunol. 145 (9): 3119–25. PMID 2212675.
Gorski J (1989). "HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes.". J. Immunol. 143 (1): 329–33. PMID 2471740.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.". Nature. 339 (6225): 548–51. doi:10.1038/339548a0. PMID 2543930.
Hurley CK, Gregersen PK, Gorski J, et al. (1989). "The DR3(w18),DQw4 haplotype differs from DR3(w17),DQw2 haplotypes at multiple class II loci.". Hum. Immunol. 25 (1): 37–50. doi:10.1016/0198-8859(89)90068-2. PMID 2565895.
Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.". J. Immunol. 141 (11): 3715–7. PMID 2846691.
Freeman SM, Saunders TL, Madden M, et al. (1987). "Comparison of DR beta 1 alleles from diabetic and normal individuals.". Hum. Immunol. 19 (1): 1–6. doi:10.1016/0198-8859(87)90033-4. PMID 2884201.
Lee BS, Rust NA, McMichael AJ, McDevitt HO (1987). "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.". Proc. Natl. Acad. Sci. U.S.A. 84 (13): 4591–5. doi:10.1073/pnas.84.13.4591. PMC 305136. PMID 2885840.
Owerbach D, Rich C, Taneja K (1986). "Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient.". Immunogenetics. 24 (1): 41–6. doi:10.1007/BF00372296. PMID 3015788.
Wu S, Saunders TL, Bach FH (1987). "Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.". Nature. 324 (6098): 676–9. doi:10.1038/324676a0. PMID 3099214.
Liu CP, Bach FH, Wu SK (1988). "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.". J. Immunol. 140 (10): 3631–9. PMID 3129499.
Steimle V, Hinkkanen A, Schlesier M, Epplen JT (1988). "A novel HLA-DR beta I sequence from the DRw11 haplotype.". Immunogenetics. 28 (3): 208–10. doi:10.1007/BF00375861. PMID 3137159.

PDB gallery

1aqd: HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

1d5m: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB

1dlh: CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE

1fv1: STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES

1fyt: CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1

1h15: X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE

1hqr: CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II

1hxy: CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II

1j8h: Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, HLA-DR4

1jwm: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3

1jws: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the Superantigen SEC3 Variant 3B1

1jwu: Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2

1kg0: Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1

1klg: Crystal structure of HLA-DR1/TPI(23-37, Thr28-->Ile mutant) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

1klu: Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

1lo5: Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II

1pyw: Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

1r5i: Crystal structure of the MAM-MHC complex

1seb: COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB

1sje: HLA-DR1 complexed with a 16 residue HIV capsid peptide bound in a hairpin conformation

1sjh: HLA-DR1 complexed with a 13 residue HIV capsid peptide

1t5w: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)

1t5x: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2

1zgl: Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a

2g9h: Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule

2iam: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

2ian: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

2icw: Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule

Image:PDB_2oje_EBI.jpg

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Surface antigens

Major histocompatibility complex/
Human leukocyte antigen

MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G

MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5 Minor histocompatibility antigen

Other

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HLA-DRB5

Function

Gene structure and polymorphisms

Gene expression

See also

References

Further reading