HIF-1 alpha IRES

HIF-1 alpha IRES
Predicted secondary structure and sequence conservation of IRES_HIF1
Identifiers
Symbol	IRES_HIF1
Rfam	RF00449
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	0043022
SO	0000243

The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1]. The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.

References

• [1] Lang, KJ; Kappel A; Goodall GJ (2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia". Mol Biol Cell. 13 (5): 1792–1801. doi:10.1091/mbc.02-02-0017. PMC 111144. PMID 12006670. 

External links

• Page for HIF-1 alpha IRES at Rfam