Guoping Feng
Guoping Feng | |
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Born | Zhejiang Province, China |
Fields | Neurobiology |
Institutions | |
Alma mater |
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Doctoral advisor | Linda Hall |
Known for | Animal models of psychiatric disease |
Notable awards |
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Guoping Feng is the Poitras Professor of Neuroscience at the McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT[2][3] and member of the Stanley Center for Psychiatric Research at Broad Institute most notable for studying the synaptic mechanisms underlying psychiatric disease.[4] In addition to developing many genetic-based imaging tools for the study of molecular mechanisms in the brain,[5] he has generated and characterized rodent models of obsessive-compulsive disorder,[6][7] autism spectrum disorders,[8] and schizophrenia.[9] Feng has also shown that some autism-like behaviors can be corrected in adult mice by manipulating the expression of the Shank3 gene.[10]
Selected publications
- Mei J, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G. (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. . Nature doi:10.1038/nature16971
- Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2012) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437–442
- Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448: 894–900
- Feng G et al. (2000) Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 28: 41–51
References
- ↑ http://newsinfo.iu.edu/news-archive/23076.html
- ↑ McGovern Institute: Guoping Feng (accessed 6 February 2016)
- ↑ MIT: Feng, Guoping (accessed 6 February 2016)
- ↑ http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
- ↑ http://www.sciencedaily.com/releases/2012/10/121017131843.htm
- ↑ http://www.nih.gov/news-events/news-releases/gene-triggers-obsessive-compulsive-disorder-syndrome-mice
- ↑ http://www.nature.com/nature/journal/v448/n7156/full/7156xiiia.html
- ↑ http://cen.acs.org/articles/90/i10/Inner-Workings-Autism.html?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+biological_scene+%28Chemical+%26+Engineering+News%3A+Biological+SCENE%29
- ↑ http://news.mit.edu/2015/shank3-gene-autism-schizophrenia-1210
- ↑ http://www.ibtimes.co.uk/autism-behaviours-reversed-mice-by-switching-shank3-gene-adulthood-1544661
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