Glycosylphosphatidylinositol phospholipase D
| Glycosylphosphatidylinositol phospholipase D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.50 | ||||||||
| CAS number | 113756-14-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.
See also
References
- ↑ Low, M.G.; Prasad, A.R.S. (1988). "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proc. Natl. Acad. Sci. USA. 85 (4): 980–984. Bibcode:1988PNAS...85..980L. doi:10.1073/pnas.85.4.980. PMC 279684
. PMID 3422494. - ↑ Malik, A.S.; Low, M.G. (1986). "Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". Biochem. J. 240 (2): 519–527. PMC 1147446. PMID 3028377.
- ↑ Li, J.Y.; Hollfelder, K.; Huang, K.S.; Low, M.G. (1994). "Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca2+ binding studies". J. Biol. Chem. 269 (46): 28963–28971. PMID 7961859.
- ↑ Deeg, M.A; Vierman, E.L.; Cheung, M.C. (2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". J. Lipid Res. 42 (3): 442–451. PMID 11254757.
External links
- Glycosylphosphatidylinositol phospholipase D at the US National Library of Medicine Medical Subject Headings (MeSH)
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