Glycoside hydrolase family 42
| Beta-galactosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of thermus thermophilus a4 beta-galactosidase | |||||||||
| Identifiers | |||||||||
| Symbol | Glyco_hydro_42 | ||||||||
| Pfam | PF02449 | ||||||||
| Pfam clan | CL0058 | ||||||||
| InterPro | IPR013529 | ||||||||
| SCOP | 1kwg | ||||||||
| SUPERFAMILY | 1kwg | ||||||||
| CAZy | GH42 | ||||||||
| |||||||||
| Beta-galactosidase trimerisation domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
crystal structure of thermus thermophilus a4 beta-galactosidase | |||||||||
| Identifiers | |||||||||
| Symbol | Glyco_hydro_42M | ||||||||
| Pfam | PF08532 | ||||||||
| Pfam clan | CL0014 | ||||||||
| InterPro | IPR013738 | ||||||||
| SCOP | 1kwg | ||||||||
| SUPERFAMILY | 1kwg | ||||||||
| |||||||||
| Beta-galactosidase C-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
crystal structure of thermus thermophilus a4 beta-galactosidase | |||||||||
| Identifiers | |||||||||
| Symbol | Glyco_hydro_42C | ||||||||
| Pfam | PF08533 | ||||||||
| Pfam clan | CL0369 | ||||||||
| InterPro | IPR013739 | ||||||||
| SCOP | 1kwg | ||||||||
| SUPERFAMILY | 1kwg | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 42 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[5]
The glycosyl hydrolase 42 family CAZY GH_42 comprises beta-galactosidase enzymes (EC 3.2.1.23). These enzyme catalyse the hydrolysis of terminal, non-reducing terminal beta-D-galactoside residues. The middle domain of these three-domain enzymes is involved in trimerisation.[6]
References
- ↑ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477
. PMID 7624375. - ↑ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
- ↑ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
- ↑ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
- ↑ Shimizu T, Kobayashi T, Ba-Thein W, Ohtani K, Hayashi H (1995). "Sequence analysis of flanking regions of the pfoA gene of Clostridium perfringens: beta-galactosidase gene (pbg) is located in the 3'-flanking region.". Microbiol Immunol. 39 (9): 677–86. doi:10.1111/j.1348-0421.1995.tb03256.x. PMID 8577281.
This article incorporates text from the public domain Pfam and InterPro IPR013529
This article incorporates text from the public domain Pfam and InterPro IPR013739
This article incorporates text from the public domain Pfam and InterPro IPR013738