Gellan tetrasaccharide unsaturated glucuronyl hydrolase
| Gellan tetrasaccharide unsaturated glucuronyl hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.179 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Gellan tetrasaccharide unsaturated glucuronyl hydrolase (EC 3.2.1.179, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp beta-D-4-deoxy-Delta4-GlcAp hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp + H2O 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp
The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases.
References
- ↑ Itoh, T.; Akao, S.; Hashimoto, W.; Mikami, B.; Murata, K. (2004). "Crystal structure of unsaturated glucuronyl hydrolase, responsible for the degradation of glycosaminoglycan, from Bacillus sp. GL1 at 1.8 Å resolution". J. Biol. Chem. 279: 31804–31812. doi:10.1074/jbc.m403288200. PMID 15148314.
- ↑ Hashimoto, W.; Kobayashi, E.; Nankai, H.; Sato, N.; Miya, T.; Kawai, S.; Murata, K. (1999). "Unsaturated glucuronyl hydrolase of Bacillus sp. GL1: novel enzyme prerequisite for metabolism of unsaturated oligosaccharides produced by polysaccharide lyases". Arch. Biochem. Biophys. 368: 367–374. doi:10.1006/abbi.1999.1305. PMID 10441389.
- ↑ Itoh, T.; Hashimoto, W.; Mikami, B.; Murata, K. (2006). "Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL1". Biochem. Biophys. Res. Commun. 344: 253–262. doi:10.1016/j.bbrc.2006.03.141. PMID 16630576.
External links
- Gellan tetrasaccharide unsaturated glucuronyl hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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