Galactosylgalactosylglucosylceramidase
galactosylgalactosylglucosylceramidase | |||||||||
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Identifiers | |||||||||
EC number | 3.2.1.47 | ||||||||
CAS number | 9023-01-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a galactosylgalactosylglucosylceramidase (EC 3.2.1.47) is an enzyme that catalyzes the chemical reaction
- D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O D-galactose + lactosyl-N-acylsphingosine
Thus, the two substrates of this enzyme are D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine and H2O, whereas its two products are D-galactose and lactosyl-N-acylsphingosine.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase. Other names in common use include trihexosyl ceramide galactosidase, ceramide trihexosidase, ceramidetrihexoside alpha-galactosidase, trihexosylceramide alpha-galactosidase, and ceramidetrihexosidase.
References
- Brady RO, Gal AE, Bradley RM, Martensson E (1967). "The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide". J. Biol. Chem. 242 (5): 1021–6. PMID 6020428.
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