GOT1

GOT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases GOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
External IDs MGI: 95791 HomoloGene: 1571 GeneCards: GOT1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

2805

14718

Ensembl

ENSG00000120053

ENSMUSG00000025190

UniProt

P17174

P05201

RefSeq (mRNA)

NM_002079

NM_010324

RefSeq (protein)

NP_002070.1

NP_034454.2

Location (UCSC) Chr 10: 99.4 – 99.43 Mb Chr 19: 43.5 – 43.52 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.[3][4]

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article

|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

  1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Bousquet-Lemercier B, Pol S, Pave-Preux M, Hanoune J, Barouki R (Sep 1990). "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection". Biochemistry. 29 (22): 5293–9. doi:10.1021/bi00474a011. PMID 1974457.
  4. 1 2 "Entrez Gene: GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)".

Further reading


This article is issued from Wikipedia - version of the 11/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.