GINS1

GINS1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E9X, 2EHO, 2Q9Q

Identifiers

GINS1, PSF1, GINS complex subunit 1

External IDs

MGI: 1916520 HomoloGene: 44516 GeneCards: GINS1

Gene ontology
Molecular function	• 3'-5' DNA helicase activity
Cellular component	• cytoplasm • GINS complex • nucleus • nucleoplasm
Biological process	• DNA replication • DNA strand elongation involved in mitotic DNA replication • DNA strand elongation involved in DNA replication • inner cell mass cell proliferation • DNA duplex unwinding
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


9837


69270


ENSG00000101003


ENSMUSG00000027454


Q14691


Q9CZ15

RefSeq (mRNA)


NM_021067


NM_001163476 NM_027014

RefSeq (protein)


NP_066545.3


NP_081290.1

Location (UCSC)

Chr 20: 25.41 – 25.45 Mb

Chr 2: 150.91 – 150.93 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
↑ Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
↑ "Entrez Gene: GINS1 GINS complex subunit 1 (Psf1 homolog)".

Further reading

Kamada K, Kubota Y, Arata T, et al. (2007). "Structure of the human GINS complex and its assembly and functional interface in replication initiation.". Nat. Struct. Mol. Biol. 14 (5): 388–96. doi:10.1038/nsmb1231. PMID 17417653.
Hayashi R, Arauchi T, Tategu M, et al. (2007). "A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.". Genomics Proteomics Bioinformatics. 4 (3): 156–64. doi:10.1016/S1672-0229(06)60028-4. PMID 17127213.
Ueno M, Itoh M, Kong L, et al. (2005). "PSF1 is essential for early embryogenesis in mice.". Mol. Cell. Biol. 25 (23): 10528–32. doi:10.1128/MCB.25.23.10528-10532.2005. PMC 1291228. PMID 16287864.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.

PDB gallery

2e9x: The crystal structure of human GINS core complex

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