GAPDHS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3H9E, 3PFW, 5C7O, 5C7L

Identifiers

Aliases

GAPDHS, GAPD2, GAPDH-2, GAPDS, HSD-35, HEL-S-278, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

External IDs

MGI: 95653 HomoloGene: 101265 GeneCards: GAPDHS

Gene ontology
Molecular function	• oxidoreductase activity • NAD binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • protein binding • NADP binding • glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Cellular component	• cytoplasm • cytosol • nucleus
Biological process	• flagellated sperm motility • gluconeogenesis • glycolytic process • positive regulation of glycolytic process • oxidation-reduction process • canonical glycolysis • glucose metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


26330


14447

Ensembl


ENSG00000105679


ENSMUSG00000061099

UniProt


O14556


Q64467

RefSeq (mRNA)


NM_014364


NM_001290631 NM_008085

RefSeq (protein)


NP_055179.1


NP_032111.1

Location (UCSC)

Chr 19: 35.53 – 35.55 Mb

Chr 7: 30.73 – 30.74 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.^[3]^[4]

Function

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.^[4]

In melanocytic cells GAPDHS gene expression may be regulated by MITF.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Welch JE, Brown PL, O'Brien DA, Magyar PL, Bunch DO, Mori C, Eddy EM (Apr 2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". Journal of Andrology. 21 (2): 328–38. doi:10.1002/j.1939-4640.2000.tb02111.x. PMID 10714828.
1 2 "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic".
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

GAPDHS

Function

Interactive pathway map

References

Further reading