Fluoroacetyl-CoA thioesterase
| Fluoroacetyl-CoA thioesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.29 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Fluoroacetyl-CoA thioesterase (EC 3.1.2.29) is an enzyme with systematic name fluoroacetyl-CoA hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- fluoroacetyl-CoA + H2O fluoroacetate + CoA
Fluoroacetate is extremely toxic.
References
- ↑ Meyer, J.J.M.; Grobbelaar, N.; Vleggaar, R.; Louw, A.I. (1992). "Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum". J. Plant Physiol. 139: 369–372. doi:10.1016/s0176-1617(11)80352-4.
- ↑ Huang, F.; Haydock, S.F.; Spiteller, D.; Mironenko, T.; Li, T.L.; O'Hagan, D.; Leadlay, P.F.; Spencer, J.B. (2006). "The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A". Chem. Biol. 13: 475–484. doi:10.1016/j.chembiol.2006.02.014. PMID 16720268.
- ↑ Dias, M.V.; Huang, F.; Chirgadze, D.Y.; Tosin, M.; Spiteller, D.; Dry, E.F.; Leadlay, P.F.; Spencer, J.B.; Blundell, T.L. (2010). "Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK". J. Biol. Chem. 285: 22495–22504. doi:10.1074/jbc.m110.107177. PMID 20430898.
External links
- Fluoroacetyl-CoA thioesterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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