FGF-2 internal ribosome entry site (IRES)
| FGF-2 internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_FGF2 | |
| Identifiers | |
| Symbol | IRES_FGF2 |
| Alt. Symbols | IRES_FGF; FGF_IRES |
| Rfam | RF00224 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | 0043022 |
| SO | 0000243 |
The FGF-2 internal ribosome entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific. It is thought that translational IRES dependent activation of FGF-2 plays a vital role in embryogenesis and in the adult brain [1]. When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and survival as well as being involved in wound-healing [1,2].
References
- [1] Creancier, L; Morello D; Mercier P; Prats AC (2000). "Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation". J Cell Biol. 150 (1): 275–281. doi:10.1083/jcb.150.1.275. PMC 2185555
. PMID 10893274. - [2] Vagner, S; Gensac MC; Maret A; Bayard F; Amalric F; Prats H; Prats AC (1995). "Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes". Mol Cell Biol. 15 (1): 35–44. PMC 231905. PMID 7799942.
External links
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